2020 Postcard from Palm Springs
Highlights from the 2020 CHDI HD Therapeutics Conference are now here! This year’s Postcard covers HTT-lowering therapeutics, including an
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NAVIGATOR – PAST RECIPIENTS
2024
Dr. Shaun Sanders (University of Guelph – lead investigator), Dr. Melanie Alpaugh (University of Guelph – co-investigator), and Dr. Dale Martin (University of Waterloo – co-investigator)
Project title: DLK as a novel therapeutic target to treat Huntington disease.
2023
Dr. Michael Hayden MBChB, PhD
University of British Columbia
Dr. Chris Kay, PhD
University of British Columbia
Project title: Determining the Role of Somatic Instability, RAN Translation, and RNA Toxicity as Mechanistic Drivers of CAG-CCG Modifier Variants in the HD Brain
2022
Prof. Cheryl Arrowsmith Ph.D
University of Toronto
Project title: Investigation of the Pathogenic Mechanisms of Synonymous HTT CAG-CCG Modifier Variants in the HD Brain
2021
Blair Leavitt, MD
University of British Columbia
Project title: Design and evaluation of an epigenetic therapeutic strategy for Huntington’s disease treatment
Mahmoud Pouladi, PhD
University of British Columbia
Project title: Investigating the impact of mutant huntingtin on human oligodendroglia
2019
Francesca Cicchetti, PhD
Université Laval
Project title: Targeting the blood brain barrier to treat Huntington’s disease
2018
Cheryl Arrowsmith, PhD
University of Toronto
Project title: Structural studies of the huntingtin protein with cryo electron microscopy
2017
Stephen Ferguson, PhD
University of Ottawa
Project title: mGluR5 as a target for the treatment of Huntington’s disease
Lynn Raymond, MD, PhD
University of British Columbia
Project title: Impaired corticostriatal synaptic plasticity in HD: Investigating a role for aberrant endocannabinoid signaling
2016
Matthew Parsons, PhD
Memorial University
Project title: Probing Novel Therapeutic Targets for the Treatment of Cognitive Decline in HD
Christopher Pearson, PhD
Hospital for Sick Children
Project title: Modulating HD CAG repeat instability for clinical benefit
2015
Michael Hayden, MD
University of British Columbia
Project title: Pre-clinical therapeutic evaluation of allele-specific mutant huntingtin suppression by antisense oligonucleotides
Blair Leavitt, MD
University of British Columbia
Project title: The contribution of microglia and neurons to HD pathogenesis
2014
Stephen Ferguson, PhD
Western University/University of Ottawa
Project title: Utility of mGluR5 antagonists for the treatment of HD
Rona Graham, PhD
Université de Sherbrooke
Project title: Role of olfactory dysfunction in HD
David Stellwagen
McGill/MUHC
Project title: TNF-mediated synaptic plasticity in Huntington’s Disease
2013
Robert Cumming
Western University
Project title: Non-canonical activation of Nrf2 as a potential therapeutic strategy for the treatment of HD
2012
Lynn Raymond, MD, PhD
University of British Columbia
Project title: Role of thalamic input in striatal dysfunction in a mouse model of HD
Simonetta Sipione
University of Alberta
Project title: Therapeutic activity of novel synthetic gangliomimetic compounds in HD
David Stellwagen
MUHC research Institute
Project title: TNF-mediated synaptic plasticity in HD
2011
Stephen Ferguson, PhD
Western University
Project title: Role of Metabotropic Glutamate Receptors in HD
Blair Leavitt, MD
University of British Columbia
Project title: Neuroinflammation in the YAC128 mouse model of HD
2010
Grant Hatch, PhD
University of Manitoba
Project title: Cardiolipin genes as biomarkes of HD
Simonetta Sipione, PhD
University of Alberta
Project title: Therapeutic use of ganglioside GM1 in HD
Ray Truant, PhD
McMaster University
Project title: Defining toxic and protective conformations of the amino-terminus of mutant huntingtin protein at the nanometer scale by use of FLIM-FRET and HRM in live cells.
2009
Francesca Cicchetti, PhD
Université Laval
Project title: Investigation of the Effects of Pathological Environment on Graft Survival in HD
Eileen Denovan-Wright, PhD
Dalhousie University
Project title: Regulation of transcription in HD
Michael Hayden, MD
University of British Columbia
Project title: The Role of HIP14-mediated Palmitoylation and Proteolysis in the Pathogenesis of HD
2008
Simonetta Sipione, PhD
University of Alberta
Project title: Role of Gangliosides in HD
2006
Francesca Cicchetti, PhD
Université Laval
Project title: In depth analysis of graft implants in a Huntington disease patient: lead into long-term graft survival, development and connectivity (integration with brain).
2005
Michael Hayden, MD
University of British Columbia
Project title: Role of huntingtin Phosphorylation in the Serine 421 (pS421) Pathogenesis of HD
2003
Janice Braun, PhD
University of Calgary
Project title: Association of N-Type Calcium Channels with Huntingtin (exp) and Huntington (nonexp)
Maxime Philbert
Université du Québec à Montréal
Project title: Attention and Inference in Huntington Disease