2026
University of British Columbia
Title of research: Identification of a Splice Variant Product in the Huntingtin (HTT) Gene
University of British Columbia
Title of research: The influence of loss of interruption variants on astrocyte reactivity in Huntington disease
University of Toronto
Title of research: Development of NanoBRET Target Engagement Assays for Huntingtin Protein
University of Windsor
Title of Research: Cell-Type-Specific Activation of the Integrated Stress Response in the Striatum of Huntington Disease Patients
University of Toronto / fellowship at University of British Columbia
Title of research: Investigating Trans-acting Genetic Modifier Variants’ Association with Loss of Interruption (LOI) Variants and Impacts on Age of Onset in Relation to Canonical Alleles
McMaster University / fellowship at University of Western Ontario
Title of research: Combining Glutamine Missense Suppressor tRNA and Antisense Oligonucleotide Therapy to Reduce Polyglutamine Aggregation in Huntington’s Disease
University of Calgary
Title of research: Brain network-based determination of genes that clear mutant huntingtin fibrils
Université de Montréal / fellowship at CHU de Québec – Université Laval
Title of research: Beyond Exon 1: Exploring the Pathogenic Role of Novel Huntingtin Aggregates in vivo.
2025
Memorial University
St. John’s, Newfoundland
Title of Research: Synaptic activity as a driver of DNA damage and somatic expansion in Huntington disease.
Université Laval
Québec City, Québec
Title of Research: Shedding light on the huntingtin protein.
University of Western Ontario
London, Ontario
Title of Research: Investigating S-Nitrosylation of MCUB in mitochondrial calcium dysregulation and HD.
McMaster University
Hamilton, Ontario
Title of Research: The use of AI-generated peptides with the CK2 kinase catalytic domain to restore Huntingtin N17 phosphorylation.
University of Waterloo
Waterloo, Ontario
Title of Research: Optimizing nanodiscs to improve antisense oligonucleotide delivery in the treatment of Huntington disease.
University of Guelph
Guelph, Ontario
Title of Research: Evaluating DLK activity in brain samples from Huntington’s disease patients.
Memorial University
St. John’s, Newfoundland
Title of Research: Synaptic activity as a driver of DNA damage and somatic expansion in Huntington disease.
University of Ottawa
Ottawa, Ontario
Title of Research: Vascular innervation and blood-brain barrier dysfunction in Huntington’s disease using human iPSC-derived vascularized brain organoids.
2024
University of Waterloo
Waterloo, Ontario
Title of Research: Computationally Driven Design and Biochemical Characterization of Improved APT1 Inhibitors as Therapeutics for the Treatment of HD.
McMaster University
Hamilton, Ontario
Title of Research: Analysis of N6FFA levels in HD human cells and knockout lines by the use of immunofluorescence and expansion microscopy.
University of Guelph
Guelph, Ontario
Title of Research: Understanding the interactions between hypertension and HD.
Memorial University
St. John’s, Newfoundland
Title of Research: Atypical NMDA receptors in Huntington’s disease.
University of British Columbia
Vancouver, BC
Title of Research: Investigating a putative modifier of HTT toxicity using cellular assays.
University of Manitoba
Winnipeg, Manitoba
Title of Research: Tracing the origin of the somatic repeat instability-related cellular phenotype in HD.
University of British Columbia
Vancouver, BC
Title of Research: Characterization of HD Brain Tissues with Loss-of-Interruption (LOI) Modifier Variants.
2023
McMaster University
Hamilton, Ontario
Title of Research: Justin joins Dr. Ray Truant this summer to define the ATM kinase site on Huntingtin and the role of ATM signaling in Huntington disease.
Queen’s University
Kingston, Ontario
Title of Research: For her research position, Tess will work with Dr. Michael Hayden to quantify single-genome assessments of CAG repeat instability in HD brain tissue with CAG-CCG modifier variants.
McGill University
Montreal, Quebec
Title of Research: Rylee will work with Dr. Adam Hendricks this summer to assess intracellular transport defects in neurodegeneration by quantifying the impacts of pathogenic polyglutamine expansions on the constituents of the Huntingtin Transport Complex.
University of Guelph
Guelph, Ontario
Title of Research: Etienne will work with Dr. Melanie Alpaugh this summer to model the human blood-brain barrier to understand the contributions of different cell types and proteins to barrier integrity.
