Skip Content
 
Page Banner Image

SIGNAL

Back to map

Sponsored by Vaccinex.

For an in-depth explanation of the trial, visit the Huntington Study Group’s web page here. 

The SIGNAL trial is designed to assess the safety, tolerability, and effectiveness of VX15, a novel monoclonal antibody, in people with late prodromal (not yet diagnosed) or early manifest (early in the progression of the disease) HD. It is a Phase 2, multi-center, randomized, double-blind, placebo-controlled study being conducted at approximately 30 sites across the United States and Canada. The trial seeks to enroll a total of 240 individuals, 21 or older.

 

 

Status
This study is currently recruiting participants.

Formal/Alternative Name
A Phase 2, Multi-center, Randomized, Double-blind, Placebo Controlled Study in Subjects With Late Prodromal and Early Manifest Huntington’s Disease (HD) to Assess the Safety, Tolerability, Pharmacokinetics, and Efficacy of VX15/2503

Study Type
Interventional

Purpose
The SIGNAL trial is a Randomized Phase 2 Study to Assess the Safety, Tolerability, Pharmacokinetics, and Efficacy of VX15/2503 in Subjects at Risk for or with Early Signs of Huntington’s Disease

Canadian Locations and Contact Information:

Edmonton, AB

Status: Recruiting
Location: University of Alberta
Coordinator: Paul McCann
Phone: 780-407-1614
Email: paul.mccann@ahs.ca

Vancouver, BC

Status: Recruiting
Location: University of British Columbia
Coordinator: Tuan Lee
Phone: 604-822-4872
Email: tle@cmmt.ubc.ca

Exclusion Criteria (eligibility that would exclude you from this study)

  • Have participated in an investigational drug or device study within 30 days of the Baseline Visit
  • Have had previous neurosurgery for HD or other movement disorders.
  • Have a history of malignancy of any type within 2 years prior to Screening.
  • Inability to undergo brain MRI.
  • Visit here for more exclusion and inclusion criteria.

Source

ClinicalTrials.gov A service of the U.S. National Institutes of Health
This study is currently recruiting participants. (see Contacts and Locations)

For more detailed information on this study and others and for the most recent updates, please go to clinicaltrials.gov ClinicalTrials.gov is a registry and results database of publicly and privately supported clinical studies of human participants conducted around the world.

 

Back to map


We support those facing huntington disease
 Latest Blog
 Questions

Questions

Let Us Know How We Can Help
Enter your name, email address and question(s) below for assistance.

 Connect
 Newsletter

Newsletter

Stay in Touch!
Enter your email address below to receive occasional updates.

Newsletter Sign-up