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Non-invasive Brain Stimulation in Huntington’s Disease

Sponsored by Western University, Canada.

Currently, studies are going on the effectiveness of noninvasive brain stimulation (NIBS) in neurodegenerative diseases. It is a mode of brain stimulation technique where current is delivered into the brain by placing electrodes into their scalp. Transcranial pulsed current stimulation (tPCS) is a new modality of noninvasive brain stimulation. It is a device that generates electrical impulses. The current generated from this device can stimulate underlying brain areas. The investigators have planned to study the feasibility of non-invasive brain stimulation via tPCS in these patients of Huntington’s disease.

At first, the investigators will rate their involuntary body movement by a standard scale, assess arm movements by a robotic device, assess speech with standard protocol, assess brain electrophysiology by electroencephalography (EEG) and will also do gait (walking) analysis. Next, the investigators will give them 2 week (20 min/day) stimulation via real tPCS (active stimulation) or placebo (sham stimulation). After 2 weeks of stimulation, the investigators will re-assess the patient using the same tools mentioned pre-stimulation.

Each patient will receive real and placebo stimulation with a 1-month gap in between. They will not know whether they are receiving real stimulation or placebo. Assessment will be done before stimulation, after 2 week real stimulation and after 2 week sham stimulation.


Formal Name
A Trial of Non-invasive Brain Stimulation in Huntington’s Disease

Study Type
Interventional (Clinical Trial)


Canadian Locations:

Location: London Health Sciences Centre
339 Windermere Road, A10-026, London, Ontario, Canada, N6A 5A5
Status: Not yet recruiting

Principal Investigator: Dr. Mandar Jog

Ages Eligible for Study: 15 Years to 75 Years (Child, Adult, Older Adult)

Sexes Eligible for Study: All

Accepts Healthy Volunteers: No

Inclusion Criteria

  • Patients of Huntington’s disease diagnosed clinically or genetically proved

Exclusion Criteria  (eligibility that would exclude you from this study)

  • Patients who can’t walk even with support, like wheel chair bound patients.
  • Patients having other issues like stroke that can aggravate speech/ gait.
  • Patients who are not able to provide informed consent.
  • Patients who are unable to communicate by speech and who can’t comprehend the English language.


For more detailed information on this study and others and for the most recent updates, please go to is a registry and results database of publicly and privately supported clinical studies of human participants conducted around the world.

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