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NAVIGATOR RECIPIENTS

2025

Dr. Blair R. Leavitt
University of British Columbia
Project title: Targeted DNA methylation editing to ameliorate Huntington’s disease phenotypes in human induced pluripotent stem cells.
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Dr. J. Alex Parker
Centre Hospitalier de l’Université de Montréal
Project title: Stimulation of Axonal Regeneration and Repair in Huntington’s Disease.
Co-Investigator: Dr. Takehiko Sasaki, Tokyo Medical and Dental University
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Dr. Lynn A. Raymond
University of British Columbia
Project title: Neurofeedback-Driven Restoration of Cortical Connectivity in HD.
Co-Investigator: Dr. Timothy H. Murphy, University of British Columbia
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Dr. Aurélie de Rus Jacquet & Dr. Francesca Cicchetti
Université Laval
Project title: Brain rejuvenation: an innovative approach to Huntington’s disease therapy.
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2024

Dr. Shaun Sanders, Dr. Melanie Alpaugh, Dr. Dale Martin
Dr. Shaun Sanders (University of Guelph – lead investigator)
Project title: DLK as a novel therapeutic target to treat Huntington disease.
Co-Investigator: Dr. Melanie Alpaugh (University of Guelph) and Dr. Dale Martin (University of Waterloo)
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2023

Dr. Chris Kay & Dr. Michael Hayden
University of British Columbia
Project title: Determining the Role of Somatic Instability, RAN Translation, and RNA Toxicity as Mechanistic Drivers of CAG-CCG Modifier Variants in the Huntington disease Brain.

2022

Cheryl Arrowsmith, PhD
University of Toronto
Project title: HTT-RNA interaction dynamics as a target of therapeutic intervention.

2021

Dr. Blair R. Leavitt
University of British Columbia
Project title: Design and evaluation of an epigenetic therapeutic strategy for Huntington’s disease treatment.
Mahmoud Pouladi, PhD
University of British Columbia
Project title: Investigating the impact of mutant huntingtin on human oligodendroglia.

2019

Francesca Cicchetti, PhD
Université Laval
Project title: Targeting the blood brain barrier to treat Huntington’s disease.

2018

Cheryl Arrowsmith, PhD
University of Toronto
Project title: Structural studies of the huntingtin protein with cryo electron microscopy.

2017

Stephen Ferguson, PhD
University of Ottawa
Project title: mGluR5 as a target for the treatment of Huntington’s disease.
Dr. Lynn A. Raymond
University of British Columbia
Project title: Impaired corticostriatal synaptic plasticity in HD: Investigating a role for aberrant endocannabinoid signaling.

2016

Matthew Parsons, PhD
Memorial University
Project title: Probing Novel Therapeutic Targets for the Treatment of Cognitive Decline in HD.
Christopher Pearson, PhD
Hospital for Sick Children
Project title: Modulating HD CAG repeat instability for clinical benefit.

2015

Dr. Michael Hayden MBChB, PhD
University of British Columbia
Project title: Pre-clinical therapeutic evaluation of allele-specific mutant huntingtin suppression by antisense oligonucleotides.
Blair Leavitt, MD
University of British Columbia
Project title: The contribution of microglia and neurons to HD pathogenesis.

2014

Rona Graham, PhD
Université de Sherbrooke
Project title: Role of olfactory dysfunction in HD.
David Stellwagen
McGill/MUHC
Project title: TNF-mediated synaptic plasticity in Huntington’s Disease.
Stephen Ferguson, PhD
Western University/University of Ottawa
Project title: Utility of mGluR5 antagonists for the treatment of HD.

2013

Robert Cumming
Western University
Project title: Non-canonical activation of Nrf2 as a potential therapeutic strategy for the treatment of HD.

2012

Simonetta Sipione
University of Alberta
Project title: Therapeutic activity of novel synthetic gangliomimetic compounds in HD.
Lynn Raymond, MD, PhD
University of British Columbia
Project title: Role of thalamic input in striatal dysfunction in a mouse model of Huntington disease.
David Stellwagen
MUHC research Institute
Project title: TNF-mediated synaptic plasticity in HD.

2011

Stephen Ferguson, PhD
Western University
Project title: Role of Metabotropic Glutamate Receptors in HD.
Blair Leavitt, MD
University of British Columbia
Project title: Neuroinflammation in the YAC128 mouse model of HD.

2010

Grant Hatch, PhD
University of Manitoba
Project title: Cardiolipin genes as biomarkes of HD.
Ray Truant, PhD
McMaster University
Project title: Defining toxic and protective conformations of the amino-terminus of mutant huntingtin protein at the nanometer scale by use of FLIM-FRET and HRM in live cells.
Simonetta Sipione, PhD
University of Alberta
Project title: Therapeutic use of ganglioside GM1 in HD.

2009

Eileen Denovan-Wright, PhD
Dalhousie University
Project title: Regulation of transcription in HD.
Francesca Cicchetti, PhD
Université Laval
Project title: Investigation of the Effects of Pathological Environment on Graft Survival in HD.
Michael Hayden, MD
University of British Columbia
Project title: The Role of HIP14-mediated Palmitoylation and Proteolysis in the Pathogenesis of HD.

2008

Simonetta Sipione, PhD
University of Alberta
Project title: Role of Gangliosides in HD.

2006

Francesca Cicchetti, PhD
Université Laval
Project title: In depth analysis of graft implants in a Huntington disease patient: lead into long-term graft survival, development and connectivity (integration with brain).

2005

Michael Hayden, MD
University of British Columbia
Project title: Role of huntingtin Phosphorylation in the Serine 421 (pS421) Pathogenesis of HD.

2003

Janice Braun, PhD
University of Calgary
Project title: Association of N-Type Calcium Channels with Huntingtin (exp) and Huntington (nonexp).
Maxime Philbert
Université du Québec à Montréal
Project title: Attention and Inference in Huntington Disease.